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Saturday, 24th October 2009

Hormonal Testing and Pharmacologic Treatment of Erectile Dysfunction: A Clinical Practice Guideline From the American College of Physicians

Hormonal Testing and Pharmacologic Treatment of Erectile Dysfunction: A Clinical Practice Guideline From the American College of Physicians
Source: Archives of Internal Medicine

The evidence regarding the utility of hormonal blood tests in identifying and affecting therapeutic outcomes for treatable causes of ED was inconclusive. The evidence demonstrated clinical benefit associated with the use of PDE-5 inhibitors regardless of the cause (such as diabetes, depression, or prostate cancer) or baseline severity of ED. The magnitude of benefit increased with severity of ED. Higher doses of sildenafil and vardenafil were associated with a modestly greater magnitude of benefit with respect to erectile function; however, this was not true for tadalafil. Overall, PDE-5 inhibitors were relatively well tolerated and were associated with mild or moderate adverse events. The incidence of adverse events did not significantly differ among the various PDE-5 inhibitors. Evidence was insufficient to determine whether PDE-5 inhibitors are associated with an increased risk for NAION.


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